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Garlic 'protects against cancer'

Scientists have uncovered fresh evidence that garlic can protect against some forms of cancer.

The research, by a team from the University of North Carolina at Chapel Hill, shows that people who eat raw or cooked garlic regularly cut their risk of stomach cancer by about a half compared with those who eat none.

They also cut their risk of colorectal cancer by as much as two-thirds.


There seems to be a strong, consistent protective effect

Professor Lenore Arab, University of North Carolina at Chapel Hill

Lead researcher Professor Lenore Arab said: "There seems to be a strong, consistent protective effect for people who are regular garlic consumers.

"It doesn't matter if they're consuming garlic in China or in the United States, the effect is still there."

However, the researchers found no such benefit from taking garlic supplements.

Professor Arab said it might be possible that this could be that the active ingredients are being destroyed in processing or by sitting on store shelves for a long time.

"Another possibility is that some of the people who turn to garlic supplements are sick already. That could skew the results."

The researchers based their findings on data from 22 previous studies from around the world on the impact of garlic on cancer.

Important compound

Professor Arab said previous research had shown that a compound in garlic called allium partially protects animals against cancer.

Some scientists believe it has the same effect in humans, she said.

Professor Arab said: "After controlling for various risk factors, we found that when we pooled the results, this preventive effect was largely confirmed.

"We didn't have enough information to be able to say the same about garlic's possible effects on other forms of cancer."

Co-researcher Professor Charles Poole warned that the possible benefits of consuming garlic might be somewhat overestimated in the study by what is called 'publication bias'.

This is the well-documented tendency of scientists and scientific publications to publish positive findings more often than results showing no effect.

"We also found the various studies were more inconsistent than we would have expected," he said.

Many scientists believe garlic helps prevent stomach cancer because it has anti-bacterial effects against a bacterium, Helicobacter pylori, found in the stomach and known to promote cancer there.

'Interesting'

A spokesman for the Cancer Research Campaign said: "It's interesting to see the results of many different studies pooled together, but it's still true that research on garlic has not led to straightforward answers.

"In order to come to any meaningful conclusions, there is a need for well-designed, large scale human studies.

"In the meantime, there's certainly no harm in including garlic as part of a healthy balanced diet."

A spokesman for the Imperial Cancer Research Fund agreed that larger studies were needed to prove the effects of eating garlic.

Rex and Christine Munday, a husband and wife research team based in New Zealand, published research earlier this year that to reduce the risk of cancer it would be necessary to eat half a clove or raw garlic a day, rising to four and half cloves if cooked.

A four-year, pan-European study was launched this summer to try to discover once and for all whether garlic does reduce the risk of cancer, and heart disease.

The research is published in the American Journal of Clinical Nutrition.

Why garlic is good for the heart

Garlic
The smell may be a healthy sign
Researchers have cracked the mystery of why eating garlic can help keep the heart healthy.

The key is allicin, which is broken down into the foul-smelling sulphur compounds which taint breath.

These compounds react with red blood cells and produce hydrogen sulphide which relaxes the blood vessels, and keeps blood flowing easily.

The University of Alabama at Birmingham research appears in Proceedings of the National Academy of Sciences.

Our results suggest garlic in the diet is a very good thing
Dr David Kraus
University of Alabama

However, UK experts warned taking garlic supplements could lead to side effects.

Hydrogen sulphide generates a smell of rotten eggs and is used to make stink bombs.

But at low concentrations it plays a vital role in helping cells to communicate with each other.

And within the blood vessels it stimulates the cells that form the lining to relax, causing the vessels to dilate.

This, in turn, reduces blood pressure, allowing the blood to carry more oxygen to essential organs, and reducing pressure on the heart.

The Alabama team bathed rat blood vessels in a bath containing juice from crushed garlic.

Striking results

This produced striking results - with tension within the vessels reduced by 72%.

The researchers also found that red blood cells exposed to minute amounts of juice extracted from supermarket garlic immediately began emitting hydrogen sulphide.

Further experiments showed that the chemical reaction took place mainly on the surface of the blood cells.

The researchers suggest that hydrogen sulphide production in red blood cells could be used to standardise dietary garlic supplements.

Lead researcher Dr David Kraus said: "Our results suggest garlic in the diet is a very good thing.

"Certainly in areas where garlic consumption is high, such as the Mediterranean and the Far East, there is a low incidence of cardiovascular disease."

Judy O'Sullivan, a cardiac nurse at the British Heart Foundation, said: "This interesting study suggests that garlic may provide some heart health benefits.

"However, there remains insufficient evidence to support the notion of eating garlic as medicine in order to reduce the risk of developing coronary heart disease.

"Having garlic as part of a varied diet is a matter of personal choice.

"It is important to note that large amounts in supplement form may interact with blood thinning drugs and could increase the risk of bleeding."

Source: BBC News

 
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